Study Supports Insomnia as Risk Factor for Depression

» Posted by on May 23, 2013 in Alpha Blog | 0 comments

Emerging research suggests a link between insomnia and dysfunctional emotional regulation.

Investigators discovered neurobiological evidence for dysfunction in neural circuitry, a finding that may have implications for relationship between insomnia and depression.

As many as 10 to 15 percent of adults have an insomnia disorder with distress or daytime impairment, and nearly 7 percent of the U.S. adult population suffers from major depressive disorder.

Both insomnia and depression are more common in women than in men.

“Insomnia has been consistently identified as a risk factor for depression,” said lead author Peter Franzen, Ph.D.

“Alterations in the brain circuitry underlying emotion regulation may be involved in the pathway for depression, and these results suggest a mechanistic role for sleep disturbance in the development of psychiatric disorders.”

Researchers followed 14 individuals with chronic primary insomnia without other primary psychiatric disorders, as well as 30 good sleepers who served as a control group.

Participants underwent an functional magnetic resonance imaging scan during an emotion regulation task in which they were shown negative or neutral pictures.

They were asked to passively view the images or to decrease their emotional responses using cognitive reappraisal, a voluntary emotion regulation strategy in which you interpret the meaning depicted in the picture in order to feel less negative.

Researchers discovered that the primary insomnia group had significantly higher activity in the amygdala brain region during reappraisal than during passive viewing.

Located deep within the temporal lobe of the brain, the amygdala plays an important role in emotional processing and regulation.

In analysis between groups, amygdala activity during reappraisal trials was significantly greater in the primary insomnia group compared with good sleepers. The two groups did not significantly differ when passively viewing negative pictures.

“Previous studies have demonstrated that successful emotion regulation using reappraisal decreases amygdala response in healthy individuals,” said Franzen. ”Yet we were surprised that activity was even higher during reappraisal of, versus passive viewing of, pictures with negative emotional content in this sample of individuals with primary insomnia.”

By Rick Nauert PhD Senior News Editor
Reviewed by John M. Grohol, Psy.D. on May 23, 2013